The pharmaceutical composition can be administered to a patient as a liquid, and gels after administration into a sustained release drug delivery system from. Evaluation of thermosensitive poloxamer 407 gel systems for. Poloxamer block copolymers are non ionic surfactants available under the. Emm 070801e00 january 2008 page 4 of 10 pluracare lf grades poloxamer applications it is suggested that these pluracare copolymers be considered for their general functionality as surfactants, emulsifiers, solubilizers and stabilizers in almost all. Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are.
Basf s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type. Article information, pdf download for safety assessment of poloxamers 101, 105, 108. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. Basf maintains a drug master file for poloxamers at the fda and is familiar with supplying. Apr 17, 2020 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Basf to develop a high purity poloxamer for mast therapeutics. Poloxamer 188 and 407 and poloxamine 908 were obtained from basf parsippany. Pluronics or poloxamers are triblock copolymers of polyethylene oxide polypropylene oxidepolyethylene oxide. A sustainedexposure formulation of ciprofloxacin microparticulates in a poloxamer named oto201 was administered during tympanostomy tube placement in children and compared to placebo and sham treatment for the prevention of tympanostomy otorrhoea. They are also used in topical dosage forms and rectal suppositories.
Download limit exceeded you have exceeded your daily download allowance. Accelon is a breakthrough omega3 technology that significantly accelerates omega3 absorption, so you get more omega3 to where its needed. Poloxamers, available also under the trademark pluronics basf, are a class of watersoluble nonionic aba and bab triblock copolymers. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric. Basf pharmaceuticalgrade ingredients for the dermatology industry. Is determined by the chain length of the polyethylene eo units and polyoxypropylene po.
Kolliphor p 338 is used primarily as thickening agent and gel former, but also as coemulsifier and consistency enhancer in creams and liquid emulsions, i. Characteristics the character of each poloxamer in terms of. Basf has been committed to the pharmaceutical industry since we introduced our original kollidon in the early 20th century. Poloxamer 188 basf pluronic f68 is widely used as a shear. Basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins.
The poloxamer synperonic f108 stock solution was stored at 4c. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of functional applications. Nov 17, 2014 commercial grades nonproprietry name commercial grades poloxamer 124 l44 poloxamer 184 l64 poloxamer 185 p65 poloxamer 188 f68 poloxamer 237 f87 poloxamer 338 f108 poloxamer 407 f127 24. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb. Commercial grades nonproprietry name commercial grades poloxamer 124 l44 poloxamer 184 l64 poloxamer 185 p65 poloxamer 188 f68 poloxamer 237 f87 poloxamer 338 f108 poloxamer 407 f127 24. However, little is known in any quantitative sense of its effect on protein adsorption and aggregation. Process for producing a poloxamer gel download pdf.
Pdf development of poloxamer gel formulations via hot. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. Use of poloxamer 188 as a membrane sealant on in vitro studies of cardiac myocytes showed signs of possible prevention of cardiomyopathy and heart failure in muscular dystrophy yasuda et al. You can find detailed information on our product range by looking up your industry or using our product finder. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Kolliphor p 407 is used primarily as thickening agent and gel former, as well as coemulsifier and consistency enhancer in creams and liquid emulsions. Modulation of protein adsorption by poloxamer 188 in. The process involves premelting the poloxamer prior to mixing with cold water.
Pdf development of poloxamer gel formulations via hotmelt. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124. Osmotic behavior of poloxamer 407 and other nonionic surfactants in aqueous solutions. Furthermore, please find here our supplier code of conduct as well as documents of accounts payable europe. Us20030206910a1 poloxamer and poloxamine compositions. Similar results were reported also for poloxamer 407lactose formulations 23 and could be explained by the interaction between water and poloxamer in the sol state.
Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Article pdf available february 2018 with 194 reads. With expertise across the entire pharmaceutical value chain we deliver on all three accounts, from lab to launch. Information material on polyurethane systems and products. The invention features selected polymers such as poloxamer 188 pluronic f68, poloxamer 237 pluronic f87, poloxamer 401 pluronic l121, poloxamer 338 pluronic f108, poloxamer 124 pluronic l44, poloxamer 184 l64, and poloxamines tetronics 904, 908, 1107, and 90r4 that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and. The purified poloxamer 407 underwent soltogel transition at lower temperature and the formed gel had a higher maximum recorded storage modulus as compared to unpurified poloxamer 407. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Together with fatty acid esters of polyethylene glycol, this forms the hydrophobic part of the product. For protection from shear stress, poloxamer 188 has a long publication history. Author links open overlay panel tacey x viegas a raymond l. All other chemical reagents and solvents were of analytical grade and used as received. The size and structure of poloxamer assemblies, and their adsorption properties 4,5, have made them useful in many applications, including. Definition, structure and therapeutic applications in cancer.
Thermogelling properties of purified poloxamer 407. Wo2009055312a1 process for producing a poloxamer gel. Basf to develop a high purity poloxamer for mast therapeutics news provided by. The effect of buffered poloxamer 407 solutions on the tonicity of bovine red blood cells was studied in the solution and gel states. Basf is committed to providing the poloxamer kolliphor p 188 bio, which is.
The osmolality of poloxamer 407 was compared against those of other block polymers and nonionic surfactants. Conditions of purchase and site regulations are important documents, which build the basis for your cooperation with basf procurement. Volume 160, issue 2, 26 january 1998, pages 157162. Pge2 and poloxamer synperonic f108 enhance transduction of. Microemulsion and poloxamer microemulsionbased gel for. Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrows challenges in drug formulation.
Download pdf 218 kb innovation 5 pages download pdf 185 kb investments and acquisitions 2 pages download pdf 118 kb business models and customer relations 1 page download pdf 62 kb working at basf 6 pages download pdf 215 kb social commitment 1 page download pdf 105 kb the basf group business year 12 pages download pdf. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. Pharmaceutics free fulltext poloxamer hydrogels for. Technical information pluracare lf grades poloxamer. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical. At basf, we know that innovation, speedtomarket, and costeffectiveness are key to pharmaceutical companies. Us20030206910a1 poloxamer and poloxamine compositions for. Osmotic behavior of poloxamer 407 and other nonionic. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Poloxamer 188mediated complement activation is an intrinsic property of.
Poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. When experts drive simple solutions, its because at basf, we create chemistry. Download fulltext pdf poloxamer hydrogels for biomedical applications article pdf available in pharmaceutics 1112. Chemicals are produced in a broad range of rigid twocomponent. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric solubilizer.
Pdf poloxamer hydrogels for biomedical applications. Pdf poloxamers, poloxamines and polymeric micelles. Data on pluronic polyols, basf wyandotte corporation, herein incorporated by reference. A thermoreversible thermoplastic pharmaceutical composition, comprising a botulinum toxin and a biocompatible poloxamer which provides thermoreversibility to the composition and additionally stabilizes the botulinum toxin, is described. Assessment of transdermal penetration enhancement by. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. Disclosed are a method for purifying poloxamers, comprising dissolving poloxamers in an organic solvent to prepare a polymer solution, and removing organometals or water from the polymer solution by at least one physical method selected from mixing of activated carbon with the polymer solution and centrifugation of the polymer solution, and poloxamers purified by the method. Evaluation of thermosensitive poloxamer 407 gel systems. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Poloxamer 188, european pharmacopoeia ep reference standard. Apr 11, 2014 poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. It possesses solubilizing, bodying and gelling properties. Owing to its ability to affect viscosity, kolliphor p 338 is also suitable as stabilizer.
It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Basf, ludwigshafen, germany was prepared in a stock solution of 100 mgml by dissolving it in sterile water overnight and filtering it through a 0. Wo20120961a2 highly pure poloxamers and purification. Basfs unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type. Pdf electrospraying poloxamer biopolymer blends using a. The only monographed poloxamer that is liquid at room temperature making it ideal for liquid dosage forms. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. Differential effects of commercialgrade and purified. The present invention is directed to a process for producing pharmaceutically acceptable aqueous poloxamer gels in a cost efficient manner. It is a surfactant functioning both as cleansing and solubilizing agent.
Today we solve unmet formulation needs and offer intelligent solutions for today and tomorrows challenges in. Download center for documents related to procurement. Strategy focused on participating in fast growing asian markets. It is often the simple solution that sorts out a complex problem. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Download fulltext pdf download fulltext pdf carbopolincorporated thermoreversible gel for intranasal drug delivery article pdf available in molecules 203.
Poloxamer solgel reversible hydrogels have attracted the attention for practical biomedical and pharmaceutical applications because of. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. Poloxamer 188 and 407 and poloxamine 908 were obtained from basf. Modulation of protein adsorption by poloxamer 188 in relation. The high performance and safety of basf products is backed by comprehensive documentation so you know you can rely on us our flexible kolliphor solutions can be used for hotmelt and spraydrying processes basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins. Despite their wide range of applications, limited analytical techniques have been reported in. Use of poloxamer 188 as a membrane sealant on in vitro studies of cardiac myocytes showed signs of possible prevention of cardiomyopathy and heart failure in. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Poloxamer 407 in conjuction with hpmc has been used for rectal delivery of quinine in children koffi et al. Autofroth specially formulated foam chemical systems take full advantage of the pressurized dispensing equipments capabilities. Causative factors behind poloxamer 188 pluronic f68, flocor. The nonclinical grade poloxamer 188 was a kind gift of basf aktiengesellschaft ludwigshafen. Download fulltext pdf development of poloxamer gel formulations via hotmelt extrusion technology article pdf available in international journal of pharmaceutics 53712 december 2017 with. Since then we have continuously expanded our solution offer.
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